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Lately everybody and their grandma have become proud armchair epidemiologists, virologists, maskologists, and vaccinologists. If I disagree with something and remind them, “actually I have a license to practice medicine”, sparks can fly. Very disconcerting.
If a clinical trial endpoint is subjective like depression, there must be a blind placebo control group. If you will blast a building and want to measure the damage, you don't need a placebo control group because this is objective. Clearly, a no-blast will show no damage.
Clinical trials require that the data collection is going to be exact. Many a trial fails when the data is audited. This is called Good Clinical Practice. #clinicaltrials
Poor sleep and meds: many people give-up quickly when there is plenty of chance to adjust dose, type, and regimen where a rotation of drug-type is often effective. #insomnia
Medication doses and formulations can differ from country to country. Creative adjustments of dose breaking pills or emptying capsules and close monitoring until the patient moves into a new stable state are good ways to handle this issue. #drugformulation #medications
Does everything need a medication on the formulary? Some things do, some don’t. Natural remedies sound “corny” and don’t make much money for medical stakeholders.
Halving or stopping meds often leads to…nothing, but that doesn’t mean there won’t be some withdrawal or recurrence. Each step of the way in medication management requires patience.
New expensive meds gets lots of praise, old cheap meds commonly get a bad rap. How should we think? Carefully. Look at data with a discerning eye, see what entities stand to benefit or loose, that usually is the best hint.
Anxiety the chameleon: sleep disturbance, nail biting, intrusive thoughts, can’t make decisions, etc. First nail-down the diagnosis! Us: https://t.co/W6SS4mCEuf, https://t.co/urVpIy8ewg
Many people are controlling in style. They don’t realize they get aggravated when others stand up for themselves, and they get upset trying to control others. Us: https://t.co/W6SS4mDcjN, https://t.co/urVpIy8MlO
Many persons stable on a medication regimen want to change to something else they hear about or friends tell them. Caution is the word! Us: https://t.co/W6SS4mCEuf, https://t.co/urVpIy8ewg
Why do some people continue to subject themselves to abuse both physically and psychologically? It’s complex but often results from a “comfort” to have distress to fight against. Us: https://t.co/W6SS4mUflN, https://t.co/urVpIxQD7G
Chronic mild depression that is up and down mixed with actual social stress often results in confusion in the person as to whether they are really ill or if it’s situational. These persons can go for decades without real help. Us: https://t.co/W6SS4mCEuf, https://t.co/urVpIy8ewg
It is common for persons to wait until their symptoms become bad before getting help then get desperate for care once things snowball. The solution is to be sure when one is going downhill. Us: https://t.co/W6SS4mCEuf, https://t.co/urVpIy8ewg
Personal disaster after disaster can cause people to give up faced with further stresses and disaster, the challenge is to break this cycle. Us: https://t.co/W6SS4mCEuf, https://t.co/urVpIy8ewg
Many patients dislike medication, they will decline increasing current medication even if they got good help from the current dose but are still have symptoms, it’s easy to forget that a little more is probably the answer. Us: https://t.co/W6SS4mCEuf, https://t.co/urVpIy8ewg